Journal of Medicinal Chemistry
Volume 42, Issue 2 (January 28, 1999)
Copyright © 1999 American Chemical Society

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PERSPECTIVE

181-201

Pharmacological Treatment of Obesity: Therapeutic Strategies Cheryl P. Kordik and Allen B. Reitz [Full Article - PDF]

COMMUNICATIONS TO THE EDITOR

202-205

5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): A Potent, Selective, and Orally Bioavailable 5-HT6 Receptor Antagonist Steven M. Bromidge, Anthony M. Brown, Stephen E. Clarke, Kathy Dodgson, Tracey Gager, Helen L. Grassam, Phil M. Jeffrey, Graham F. Joiner, Frank D. King, Derek N. Middlemiss, Stephen F. Moss, Helen Newman, Graham Riley, Carol Routledge, and Paul Wyman [Full Article - PDF]

206-209

Bis- and Mixed-Tetrahydroisoquinolinium Chlorofumarates: New Ultra-Short-Acting Nondepolarizing Neuromuscular Blockers Eric E. Boros, Eric C. Bigham, G. Evan Boswell, Robert A. Mook, Jr., Sanjay S. Patel, John J. Savarese, John A. Ray, James B. Thompson, Mir A. Hashim, James C. Wisowaty, Paul L. Feldman, and Vicente Samano [Full Article - PDF]

210-212

Discovery of a Potent, Orally Active, Nonsteroidal Androgen Receptor Agonist: 4-Ethyl-1,2,3,4-tetrahydro-6- (trifluoromethyl)-8-pyridono[5,6-g]- quinoline (LG121071) Lawrence G. Hamann, Neelakandha S. Mani, Robert L. Davis, Xiao-Ning Wang, Keith B. Marschke, and Todd K. Jones [Full Article - PDF]

EXPEDITED ARTICLES

213-220

Antagonists of the Platelet P2T Receptor: A Novel Approach to Antithrombotic Therapy Anthony H. Ingall, John Dixon, Andrew Bailey, Mandy E. Coombs, David Cox, Judith I. McInally, Simon F. Hunt, Nicholas D. Kindon, Barry J. Teobald, Paul A. Willis, Robert G. Humphries, Paul Leff, Jane A. Clegg, James A. Smith, and Wendy Tomlinson [Full Article - PDF]

ARTICLES

221-228

Mechanism-Based Competitive Inhibitors of Glyoxalase I: Intracellular Delivery, in Vitro Antitumor Activities, and Stabilities in Human Serum and Mouse Serum Malcolm J. Kavarana, Elena G. Kovaleva, Donald J. Creighton, Megan B. Wollman, and Julie L. Eiseman [Full Article - PDF]

229-241

New Bicyclam-AZT Conjugates: Design, Synthesis, Anti-HIV Evaluation, and Their Interaction with CXCR-4 Coreceptor Jean Dessolin, Pascale Galea, Patrick Vlieghe, Jean-Claude Chermann, and Jean-Louis Kraus [Full Article - PDF]

242-248

Domain-Structured N-Derivatized Hydrazines as Inhibitors of Ribonucleoside Diphosphate Reductase: Redox-Cycling Considerations Shalom Sarel, C. Fizames, Francois Lavelle, and Shelly Avramovici-Grisaru [Full Article - PDF]

249-259

Three-Dimensional Quantitative Structure-Activity Relationship Study on Cyclic Urea Derivatives as HIV-1 Protease Inhibitors: Application of Comparative Molecular Field Analysis Asim Kumar Debnath [Full Article - PDF]

260-266

Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin S. Mark Roe, Chrisostomos Prodromou, Ronan O'Brien, John E. Ladbury, Peter W. Piper, and Laurence H. Pearl [Full Article - PDF]

267-276

Novel Esters and Amides of Nonsteroidal Antiinflammatory Carboxylic Acids as Antioxidants and Antiproliferative Agents Mark R. Hellberg, Abdelmoula Namil, Pete Delgado, Karen C. David, Timothy L. Kessler, Gustav Graff, Karen S. Haggard, and Jon C. Nixon [Full Article - PDF]

277-290

Structure-Immunosuppressive Activity Relationships of New Analogues of 15-Deoxyspergualin. 1. Structural Modifications of the Hydroxyglycine Moiety Luc Lebreton, Jocelyne Annat, Philippe Derrepas, Patrick Dutartre, and Patrice Renaut [Full Article - PDF]

291-299

Ab Initio Conformational Study of the Phenylisoserine Side Chain of Paclitaxel Marco Milanesio, Piero Ugliengo, and Davide Viterbo , Giovanni Appendino [Full Article - PDF]

300-304

Orally Active, Hydrolytically Stable, Semisynthetic, Antimalarial Trioxanes in the Artemisinin Family Gary H. Posner, Michael H. Parker, John Northrop, Jeffrey S. Elias, Poonsakdi Ploypradith, Suji Xie, and Theresa A. Shapiro [Full Article - PDF]

305-311

Vasopeptidase Inhibitors: Incorporation of Geminal and Spirocyclic Substituted Azepinones in Mercaptoacyl Dipeptides Jeffrey A. Robl, Richard Sulsky, Ellen Sieber-McMaster, Denis E. Ryono, Maria P. Cimarusti, Ligaya M. Simpkins, Donald S. Karanewsky, Sam Chao, Magdi M. Asaad, Andrea A. Seymour, Maxine Fox, Patricia L. Smith, and Nick C. Trippodo [Full Article - PDF]

312-323

N-[2,2-Dimethyl-3-(N-(4-cyanobenzoyl)amino)nonanoyl]-L-phenylalanine Ethyl Ester as a Stable Ester-Type Inhibitor of Chymotrypsin-like Serine Proteases: Structural Requirements for Potent Inhibition of -Chymotrypsin Kiyoko Iijima, Jun Katada, Emiko Yasuda, Isao Uno, and Yoshio Hayashi [Full Article - PDF]

BRIEF ARTICLES

324-328

Synthesis and Evaluation of 2-Amino-9-(1,3-dihydroxy-2-propoxymethyl)- 6-fluoropurine Mono- and Diesters as Potential Prodrugs of Ganciclovir Dae-Kee Kim, Kieyoung Chang, Guang-Jin Im, Hun-Taek Kim, Namkyu Lee, and Key H. Kim [Full Article - PDF]

329-332

2,6-Difluorophenol as a Bioisostere of a Carboxylic Acid: Bioisosteric Analogues of -Aminobutyric Acid Jian Qiu, Scott H. Stevenson, Michael J. O'Beirne, and Richard B. Silverman [Full Article - PDF]